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Evista (Raloxifene)

It is believed that breast pain is caused by abnormal sensitivity of breast tissue to normal levels of the hormones prolactin and oestrogen. There is increasing evidence that this abnormality is related to low levels of essential fatty acids, high levels of saturated fatty acids, and a defect in lipid metabolism.
Breast pain appears to be common in countries where people eat a lot of saturated fat, and it has been shown that breast symptoms improve if the amount of saturated fat is reduced.
Women with breast pain may have lower than normal levels of GLA and its metabolites, and higher than normal levels of saturated fatty acids. This pattern is likely to sensitize tissues to oestrogen, since oestrogen receptors have a greater affinity for the hormone if they are in a membrane environment which is rich in saturated fats and low in polyunsaturated essential fatty acids, such as GLA and its metabolites.
The changes in fatty acid composition could explain why the breast appears to be unduly sensitive to normal amounts of oestrogen.
There is an interesting relationship between heart disease in men and mastalgia and PMS in women. In societies where there is a high rate of death from heart disease among young
And middle-aged men, there is a correspondingly high rate of breast disease and PMS in young and middle-aged women, ST wherever saturated fat intake is high relative to the intake of essential fatty acids, breast and menstrual cycle disorders become common.
If a high intake of saturated fat is associated with benign breast disease and other disorders, then increasing the intake of polyunsaturated fatty acids may reverse or prevent the development of mastalgia and PMS.
Women with breast disease tend to have high rates or sebum production, which is a marker of EFA deficiency. Also, PGE1 inhibits some of the peripheral actions of prolactin, a hormone which has been implicated in both breast and menstrual cycle problems.
A shortage of essential fatty acids in the diet leads to excessive amounts of fibrous tissue. Cysts, which are another common symptom of mastalgia, may form because for some reason the body is making too much of the hormone prolactin, and is also short of prostaglandin EX.
The idea behind giving evening primrose oil as a treatment for breast pain is that PGE1 can dampen down the effects of prolactin, may help the development of cysts, and can help remove lumpiness in the breasts.

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