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Estrace (Estradiol)

Women with breast pain have been found to have normal, or near normal levels of linoleic acid However, they have abnormally low levels of the metabolites of linoleic acid.
For some reason, these women are not metabolizing linoleic acid successfully. This may be because the conversion of linoleic acid to the next stage, GLA, is slowed down or blocked by such things as stress, a high saturated fat diet, or a high alcohol intake. For whatever reason, something is inhibiting the activity of the delta-6-desaturase enzyme, which is needed to convert linoleic acid to its metabolites.
Evening primrose oil works because its active ingredient is GLA, which by-passes the metabolic block. So the level of essential fatty acids is brought up to normal.
By normalizing the level of essential fatty acids, the metabolic cause behind the abnormal sensitivity to hormones’ is corrected.
A total of 188 women have been studied in double-blind, placebo-controlled studies carried out at the University Hospital of Wales in Cardiff, at Ninewells Hospital in Dundee, and at Plymouth General Hospital. The length of trial and the doses given were different in each centre: 8x500mg per day in Cardiff (2 months) and Plymouth (5 months), and 6x500mg in Dundee (3 months). Women with breast pain not due to cancer or any other obvious cause were entered into the trials, and received at random either the treatment (evening primrose oil), or a placebo. Most of the patients in the trial – 141 – had cyclic symptoms. The other 47 had non-cyclic.
The women were seen at the start of the trial then again at monthly intervals in the pre-menstrual phase of their cycle. Each woman assessed the severity of pain and other breast symptoms, in particular lumpiness, heaviness and tenderness.

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