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Glucovance (Glyburide)

PUVA (oral psoralen plus ultraviolet A light) is a special form of ultraviolet A light which is highly effective in treating psoriasis. It was first developed in the early 1970s and is still the most effective treatment available. PUVA involves taking one tablet of Psoralen two hours before exposure to ultraviolet A light. Psoralen sensitizes the skin to the ultraviolet A light, causing the psoriasis to disappear over twenty to thirty treatment sessions.
The main problems with PUVA therapy are the risk of long-term skin cancer and premature ageing of the skin. Special eye protection is also necessary, as the Psoralen tablets also sensitize the eyes to ultraviolet light.
In order to minimize the risk of skin cancer, it is best to combine PUVA therapy with Tigason, which is also taken in tablet form. It is also advisable to cover areas of the body that do not have psoriasis such as the hands, face and genital regions. More recently, ‘bath’ PUVA has become popular. Rather than taking a tablet prior to ultraviolet A light exposure, the sufferer is bathed in a special Psoralen solution which sensitizes the skin to ultraviolet A light.

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