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Actoplus Met (Metformin and Pioglitazone)

Diabetic retinopathy is a condition in which the small blood vessels supplying the light-sensitive retina at the back of the eye become damaged. Eventually they can no longer supply nutrients and the starved retina releases an unknown factor which encourages proliferation of new vessels. Unfortunately these grow forwards away from the retina into the clear jelly or vitreous through which we see. The new vessels can tear and bleed into the vitreous, obstructing vision.
Such severe proliferative retinopathy is uncommon. Generally the only sign that the diabetic process is affecting the eye is what is called microaneurysm formation, when tiny red dots can be seen on or near the damaged blood vessels. These very early changes can be seen through an ophthalmoscope (a magnifying torch shone through the pupil of the eye) and warn of the development of retinopathy. Microaneurysms do not affect vision, but hemorrhages and fatty deposits (exudates) may also start to form on the retina. If these exudates lie over the area of best vision, which is called the macula (see the diagram opposite), sight may be impaired.
Diabetic retinopathy
1 Can be detected at an early stage
2. Can be treated successfully
3 May be prevented by careful attention to glucose control.

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