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Avapro (Irbesartan)

This is a difficult question. As often, we know more about rats than man. Rats eat to meet their energy needs. Exercise them and they increase food intake; their weight remains level. Feed them diluted or concentrated food: they eat a bigger or smaller volume and preserve their figures.
We too have some ability to match eating to energy needs; most of us do not change much in weight during adult life. We do not stay constant from day to day, but our weight fluctuates around a steady average value. This is quite an achievement: we may eat half a ton of food in a year, but few of us gain or lose more than four or five pounds.
But life is more complex for us than for the rat. Food is abundant in our affluent societies; we learn to eat for pleasure and as a social ritual rather than to relieve hunger. Sometimes we eat for solace or out of boredom. Our life style has overruled the hunger signal on which the rat relies. In addition, ours is a sedentary way of life; the internal-combustion engine has seen to that. Our opportunities to expend food energy have become small compared with those of our ancestors of even five to ten generations ago. Even the rat’s regulation of appetite breaks down when his physical activity is restricted, as Dr Jean Mayer has found at Harvard University.
Today, the leanest person is likely to be healthiest. This was not always the case. For our ancestors fat was a protection against cold, and a provision against food scarcity. Inherited obesity could have helped them survive; now, as Dr J. F. Neel suggests, a ‘thrifty genotype’ may be a disadvantage – in our food-abundant sedentary society it may predispose to obesity and shorten life.

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