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Rifater (Rifampin, Isoniazid, Pyrazinamide)

Other names: Rifampicin
Cautionary notes
Before starting NSAID therapy discuss the following with your physician:
• A history of allergy to aspirin or other anti-inflammatory medication. Symptoms of allergy include rash, hives, wheezing, and swollen lips or eyelids.
• Previous history of asthma, nasal polyps, stomach ulcer, bleeding problems, colitis, high blood pressure, and kidney or liver problems.
• Any medications you are taking, particularly medications for blood thinning, diabetes, gout, high blood pressure, pain, or seizures.
While taking NSAIDs:
• Contact your physician promptly if you notice dark or tar-colored bowel movements, persistent indigestion or nausea, stomach pain that is relieved by eating.
• Never take more than one NSAID at a time. If your doctor prescribes a new NSAID, he or she will almost certainly take you off the other; if he or she fails to discuss this with you, you should ask about it. Do not take over-the-counter anti-inflammatory medications such as ibuprofen and aspirin while you are taking an NSAID. If your physician approves, acetaminophen (Tylenol) may be taken while you are taking an NSAID.
• Unless you are instructed otherwise, you should take the NSAID at mealtime to reduce indigestion and stomach irritation.
• Inform your dentist, surgeon, and anyone else performing health care procedures that you are taking an NSAID.
• Wait two to four weeks before judging the effectiveness of the NSAID.
• Avoid drinking alcohol and smoking because these practices increase your risk of developing an ulcer.
• Your doctor may periodically request blood tests for blood cell counts, kidney and liver tests, and tests for electrolyte (sodium and potassium) levels, as well as examine your stool for blood.
Pregnancy and Breastfeeding
Not all NSAIDs have been studied adequately as to their effects on pregnancy, but it is generally recommended that they be discontinued during pregnancy. Most NSAIDs are excreted to some degree in the breast milk, and hence their use is usually discouraged during nursing. The manufacturer’s package insert can be reviewed by you and your physician for information about the use of a specific NSAID during pregnancy and nursing. Discuss all medications with your obstetrician and your pediatrician.

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