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Furoxone (Furazolidone)

On the face of it, eczema, asthma, hay fever and allergies all sound like very different conditions. But in fact they have a lot in common – they are all to do with an abnormal body defense system. Doctors call this condition ‘atopy’.
In fact atopy – or a generalized allergic response – can show itself as any or all of a variety of conditions. As many as one in five of the population suffers from some sort of atopy (though this term is virtually unknown by the layman). Atopy is common in patients with ulcerative colitis, Crohn’s disease, ear problems, nasal polyps, and some obstetric problems.
Atopic eczema is closely linked with other atopic conditions like asthma and hay fever, and it is common to find other members of the family suffering from these things. In some ways, atopic eczema behaves like a type of asthma where the patient is a little short-winded virtually all the time and occasionally has real difficulty in breathing. In one person the atopy shows up as eczema, but in another person it might take the form of, say, asthma.
There are several things in common between eczema, asthma, allergies and other atopic conditions:
1. Faulty immune response. It has been known for a long time that people with eczema, asthma and allergies have something wrong with their immune system. There is some speculation that the abnormalities of the immune system in atopic disease are partly secondary consequences of a disordered fatty acid metabolism. If there is a fatty acid abnormality, various parts of the immune system or things which regulate the immune system are badly affected, particularly PGE1 and the T-lymphocytes. The abnormal fatty acid composition found in people with atopic eczema has similarities with cases of respiratory allergy.
2. Faulty enzyme function. Atopic people may have a defect in the delta-6-desaturase enzyme, which is needed to convert linoleic acid to GLA. The fact that evening primrose oil works in atopic eczema means that the enzyme block can be bypassed, which would indicate that a defective enzyme is the guilty party. This may also be the case with other atopic conditions.
The blocking agents are inhibitors of the delta-6-desaturase enzyme. So people with atopic conditions must be more careful about the things which cause disruption to an already defective enzyme system. The main ones are:
• Trans fatty acids
• Too much saturated fat
• Simple sugars
• Alcohol
• Catecholamines – hormones released by adrenal glands during stress
Evening primrose oil does nothing to correct the actual defective enzyme. But, by starting at step 2 in the conversion process of linoleic acid, it gives the body enough essential fatty acids for everything to be able to work properly.
So evening primrose oil helps correct the faulty immune system in people with atopic conditions. This is because it converts to PGE1, which stimulates the T-lymphocytes, which play a key role in the immune system. T-suppressor lymphocytes are a type of white blood cell which seem to keep other parts of the immune system under control and which make sure that the immune system first and foremost attacks foreign invaders, like bacteria and viruses, and not the body’s own tissues.
It seems that the T-lymphocytes, especially T-suppressor cells, are faulty in people with atopic conditions. When T-suppressor cells are defective, auto-immune damage often happens.

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