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Sporanox (Itraconazole)

Most of the body iodine is present in the thyroid gland, but all cells contain minute traces. Iodine is a constituent of two hormones, thyroxine and thyroglobulin. These hormones (1) regulate energy metabolism, (2) are involved in the synthesis of protein and cholesterol, and (3) facilitate the conversion of carotene to vitamin A.
Iodine is rapidly absorbed from the gastrointestinal tract and stored in the thyroid gland. Intakes in excess of body needs are promptly excreted in the urine.
The allowance for iodine for men and women is 150 mcg. Foods grown along the seacoast, saltwater fish, and shellfish are good sources. Breads to which iodates have been added as a dough conditioner are also good sources. The most reliable way to ensure an adequate intake of iodine is through the use of iodized salt.
Clinical problems
A deficiency of iodine leads to a decreased production of thyroxine, and, in turn, a lowered rate of energy metabolism. In an attempt to produce more thyroid hormones the thyroid gland enlarges. This condition is called simple or endemic goiter. In a mild deficiency the only symptom noted is a slight enlargement of the thyroid gland, visible at the neckline. However, if the condition persists, the woman who has a simple goiter and who fails to get sufficient iodine during pregnancy will be unable to supply the fetus with its needs; thus, the baby is more severely affected than its mother was. When the deficiency is severe, growth is retarded and mentality is dulled.
Simple goiter, once frequently seen in the Midwestern states where the soil content of iodine is low, now occurs rarely in the United States. The use of iodized salt is credited with this decline. Endemic goiter is still a major problem in some Central and South American countries, Asia, and Africa.

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