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Advair Diskus (Fluticasone, Salmeterol)

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THE ALLERGIC REACTION
There are five different classes of immunoglobulins in the body. These are known as IgG, IgA, IgM, IgD and IgE. IgG is the principal immunoglobulin in the blood and internal fluids. Its job is to remove soluble antigens from the body, in conjunction with other immune complexes. IgA, and to a lesser extent IgM are the main secretory immunoglobulins. They form a protective coating on the body’s mucosa, thereby limiting entrance of antigens through the mucosa surfaces, such as in the nasal passages and the gut. Evidently, the physiological functions of IgD and IgE are not fully understood. It is thought that IgE may play an important part in ridding the body of mucosal infection but is ineffective in ecological illness. On the other hand, IgD may act as the trigger to initiate immune responses as it has been observed that, when a mucosal surface is under attack by antigens, initiation of IgE production is dependent upon a lymphocyte that contains IgD.
When the antigen is an allergenic substance (the allergen), the leucocytes and immunoglobulins are unable to cope with it. The antibody and the antigen react, causing a malfunction in the body’s defences. The mast cells, which are found in mucous membrane and connective tissue, break up. As a result, chemicals such as histamine, are released and these cause irritation and damage.
Some antigens may reach the bloodstream by way of the body’s mucous surfaces. There, they attach themselves to red and white cells or form immune complexes with specific antibodies. These are carried around the body and can cause direct tissue injury, for example a precipitate in connective tissue which can block small blood vessels. This results in fever, aching, muscle pains, and can happen after eating a certain food. Those mysterious, but troublesome, back and joint pains which appear to have no rational cause, can be the result of an allergic reaction. Alternatively, the symptoms may not relate to a specific ‘target’ area. Instead, inflammation and fever may occur over the entire body. This can make it difficult to identify as an allergic reaction.
When inflammation or fever occurs as part of the immune response, it may be localized at an area of infection or be dispersed throughout the entire body. If the latter happens, the body temperature will increase and cause greater enzyme activity. This in turn, increases the metabolic rate; providing extra energy for the production of the leucocytes and immunoglobulins needed to fight the invading antigens. Although, in the case of an allergic reaction, this process is not successful, it may explain why allergy sufferers, particularly of food and chemical allergies, often tend to feel overheated.
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